Bronchicine CAe is used for the vaccination of normal, healthy puppies and dogs as an aid in the control of canine infectious tracheobronchitis (canine cough) caused by Bordetella bronchiseptica. The new formulation process significantly removes extraneous gram-negative cellular debris, proteinaceous material, and lipopolysaccharides. Ready to use, does not require reconstitution. Non-adjuvanted, which minimizes local reactions. Unique Cellular Antigen extraction process antigenic potency and minimizes potential for reactions. Single-antigen vaccine. Easily supplements vaccination programs and provides planned protection against canine cough. All vaccines are shipped Express 1-2 Days. A $29.95 flat rate fee is charged for all orders containing vaccines. Someone should be present to sign for and receive the vaccine order when it ships to you. For more shipping info click here. NOTE: This item cannot be shipped to Minnesota, Canada and P.O. Boxes. Use must be approved by your veterinarian.