Endovac-Equi with ImmunePlus is for the vaccination of healthy horses 6 months of age and older to aid in the prevention of endotoxin-mediated diseases caused by Salmonella typhimurium and Escherichia coli. Equine endotoxemia vaccine Protects against E. Coli and Salmonella For horses and foals 6 months of age and older No mixing required All vaccines are shipped Express 1-2 Days. A $29.95 flat rate fee is charged for all orders containing vaccines. Someone should be present to sign for and receive the vaccine order when it ships to you. For more shipping info click here. NOTE: This item cannot be shipped to Minnesota, Canada and P.O. Boxes. Use must be approved by your veterinarian.