Veterinarian formulated and recommended for dogs over the age of 12 weeks. Advanced Calming Support helps to balance the serotonin and dopamine levels and provides neuromuscular support for a complete synergistic calming approach. Perfect for dogs exhibiting nervousness, hyperactivity, discontentment or responding to environmentally induced stress. Helps maintain contentment during separation, travel, motion sickness, storms, fireworks, and changes in daily routine.