No Thrush Canine provides approximately 30 applications for hot spots and ear problems (more if the hot spots are small.) Simply shake the bottle, snip the tip, and puff NT powder onto the problem area. Gently rub it into skin... and that's it.. Use 1-3 times per day. Most hot spots clear up in 3-4 days. A Powdered Natural Solution Also Used on abrasions, bug and flea bites. Made in the U.S.A.