For subcutaneous vaccination of healthy dogs 6 weeks of age or older as an aid in the prevention of disease caused by canine distemper, infectious canine hepatitis, canine adenovirus type 2, canine coronavirus and canine parvovirus (CPV). This product contains a CPV 2b strain which has been demonstrated to aid in the prevention of disease caused by CPV 2c in puppies with CPV maternal antibody. Directions: Aseptically rehydrate ULTRA Duramune DAP with low volume diluent supplied. Administer one 0.5 mL dose subcutaneously. A recommended vaccination schedule should start at or about 6 weeks of age. The presence of maternal antibody is known to interfere with the development of active immunity. Puppies should be revaccinated every 2 to 3 weeks until at least 12 weeks of age. All dogs over 12 weeks of age should initially receive one dose of this product and a second dose 2 to 3 weeks later. Annual revaccination with one dose is recommended. All vaccines are shipped overnight. A $29.95 flat rate fee is charged for all orders containing vaccines. Someone should be present to sign for and receive the vaccine order when it ships to you. For more shipping info click here.