Zymox Plus with BioFilm Reducing Formula works on resistant microbes quicker and more effectively.Zymox Plus helps animals with acute and chronic otitis externa due to resistant pseudomonas and similar biofilm forming microbes. This condition is caused by harmful microbes that form complex biofilm, including: Pseudomonas, Staphylococcus aureus, Coagulase-negative staphylococci, Methicillin-resistant Staphylococcus aureus (MRSA). Zymoc Plus destroys the difficult to penetrate biofilm and breaks the cycle of chronic infection by increasing the potency of the antimicrobial LP3 Enzyme System, as well as four additional enzymes. Try this formula if your pet continues to suffer from infection, or has an infection that will not heal. Apply into the ear of your dog or cat once a day without cleaning the ear before or during use. Aids in the treatment of chronic otitis externa For dogs and cats How to Use: Shake well before use. Apply liberally to un-cleaned ear, filling the ear canal. Gently massage and work into infected area. Wipe to remove excess. Allow the animal to shake head. Use 1x daily for 5- 14 days. Safe for extended use on persistent cases. Contraindicated in cases of ruptured or punctured eardrums. Not for use on pregnant or lactating females. Keep out of reach of children. For Animal Use only.