Zymox Plus Otic Enzymatic Solution with Biofilm Reducing Formula Works on Resistant Microbes Quicker and More Effectively. Features increased potency of the patented LP3 Enzyme System PLUS four additional biofilm-reducing enzymes formulated to destroy the hard-to-penetrate biofilm slime layer that protects and hides microbes. Engineered to aid in the management of the toughest chronic otitis externa cases ? those due to resistant organisms, such as pseudomonas or even MRSA which form complex biofilm. Ideal for those cases of repeated infection or the infection that just won?t resolve. Same broad spectrum antibacterial, antifungal properties PLUS biofilm reduction. Biofilm is an ill-defined mix of polysaccharides, nucleic acids and proteins encased in a slimy matrix. The four additional enzymes in Zymox PLUS work synergistically to attack this mix to break down the complex structure, prevent adhesion and metabolize the biofilm components. When combined with the patented antimicrobial LP3 Enzyme System, the results are antibacterial and antifungal with effective biofilm destruction. As in all the Zymox products work best in a ?dirty? environment ? NO Pre-Cleaning is required.