Zymox Plus Otic-HC Enzymatic Solution helps manage the toughest chronic ear infections. It features increased potency of the patented LP3 Enzyme System plus four additional enzymes to break down the hard-to-penetrate biofilm slime layer that protects and hides microbes. Ideal for cases of repeated infection or the chronic infection that just won't go away. Active ingredient: Hydrocortisone 1.0%. Made in USA. Do not use on punctured ear drums or on pregnant or lactating females.